This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Comment

. 2009 Oct;19(10):1693-5.

doi: 10.1101/gr.098376.109.

Darwinian alchemy: Human genes from noncoding DNA

Affiliations

Affiliation

¹ Department of Biological Statistics and Computational Biology, Cornell Center for Comparative and Population Genomics, Cornell University, Ithaca, New York 14853, USA. acs4@cornell.edu

PMID: 19797681
PMCID: PMC2765273
DOI: 10.1101/gr.098376.109

Comment

Darwinian alchemy: Human genes from noncoding DNA

Adam Siepel. Genome Res. 2009 Oct.

. 2009 Oct;19(10):1693-5.

doi: 10.1101/gr.098376.109.

Author

Affiliation

¹ Department of Biological Statistics and Computational Biology, Cornell Center for Comparative and Population Genomics, Cornell University, Ithaca, New York 14853, USA. acs4@cornell.edu

PMID: 19797681
PMCID: PMC2765273
DOI: 10.1101/gr.098376.109

No abstract available

PubMed Disclaimer

Comment on

Recent de novo origin of human protein-coding genes.
Knowles DG, McLysaght A. Knowles DG, et al. Genome Res. 2009 Oct;19(10):1752-9. doi: 10.1101/gr.095026.109. Epub 2009 Sep 2. Genome Res. 2009. PMID: 19726446 Free PMC article.

Similar articles

Contrasting patterns of sequence divergence and base composition between Drosophila introns and intergenic regions.
Ometto L, De Lorenzo D, Stephan W. Ometto L, et al. Biol Lett. 2006 Dec 22;2(4):604-7. doi: 10.1098/rsbl.2006.0521. Biol Lett. 2006. PMID: 17148300 Free PMC article.
Patterns of evolutionary constraints in intronic and intergenic DNA of Drosophila.
Halligan DL, Eyre-Walker A, Andolfatto P, Keightley PD. Halligan DL, et al. Genome Res. 2004 Feb;14(2):273-9. doi: 10.1101/gr.1329204. Genome Res. 2004. PMID: 14762063 Free PMC article.
The search for meaning in noncoding DNA.
Clark AG. Clark AG. Genome Res. 2001 Aug;11(8):1319-20. doi: 10.1101/gr.201601. Genome Res. 2001. PMID: 11483570 No abstract available.
Functional evolution of noncoding DNA.
Ludwig MZ. Ludwig MZ. Curr Opin Genet Dev. 2002 Dec;12(6):634-9. doi: 10.1016/s0959-437x(02)00355-6. Curr Opin Genet Dev. 2002. PMID: 12433575 Review.
The evolution of noncoding DNA: how much junk, how much func?
Castillo-Davis CI. Castillo-Davis CI. Trends Genet. 2005 Oct;21(10):533-6. doi: 10.1016/j.tig.2005.08.001. Trends Genet. 2005. PMID: 16098630 Review.

See all similar articles

Cited by

Phylogenetic patterns of emergence of new genes support a model of frequent de novo evolution.
Neme R, Tautz D. Neme R, et al. BMC Genomics. 2013 Feb 21;14:117. doi: 10.1186/1471-2164-14-117. BMC Genomics. 2013. PMID: 23433480 Free PMC article.
The Recent De Novo Origin of Protein C-Termini.
Andreatta ME, Levine JA, Foy SG, Guzman LD, Kosinski LJ, Cordes MH, Masel J. Andreatta ME, et al. Genome Biol Evol. 2015 May 21;7(6):1686-701. doi: 10.1093/gbe/evv098. Genome Biol Evol. 2015. PMID: 26002864 Free PMC article.
De novo origin of protein-coding genes in murine rodents.
Murphy DN, McLysaght A. Murphy DN, et al. PLoS One. 2012;7(11):e48650. doi: 10.1371/journal.pone.0048650. Epub 2012 Nov 21. PLoS One. 2012. PMID: 23185269 Free PMC article.
A human-specific de novo protein-coding gene associated with human brain functions.
Li CY, Zhang Y, Wang Z, Zhang Y, Cao C, Zhang PW, Lu SJ, Li XM, Yu Q, Zheng X, Du Q, Uhl GR, Liu QR, Wei L. Li CY, et al. PLoS Comput Biol. 2010 Mar 26;6(3):e1000734. doi: 10.1371/journal.pcbi.1000734. PLoS Comput Biol. 2010. PMID: 20376170 Free PMC article.
Identification, characterization and expression analysis of lineage-specific genes within sweet orange (Citrus sinensis).
Xu Y, Wu G, Hao B, Chen L, Deng X, Xu Q. Xu Y, et al. BMC Genomics. 2015 Nov 23;16:995. doi: 10.1186/s12864-015-2211-z. BMC Genomics. 2015. PMID: 26597278 Free PMC article.

See all "Cited by" articles

References

1. Begun DJ, Lindfors HA, Kern AD, Jones CD. Evidence for de novo evolution of testis-expressed genes in the Drosophila yakuba/Drosophila erecta clade. Genetics. 2007;176:1131–1137. - PMC - PubMed
1. Bridges C. Salivary chromosome maps. J Hered. 1935;26:60–64.
1. Buhl AM, Jurlander J, Jorgensen FS, Ottesen AM, Cowland JB, Gjerdrum LM, Hansen BV, Leffers H. Identification of a gene on chromosome 12q22 uniquely overexpressed in chronic lymphocytic leukemia. Blood. 2006;107:2904–2911. - PubMed
1. Buhl AM, Novotny GW, Josefsson P, Nielsen JE, Pedersen LB, Geisler C, Rassenti LZ, Kipps TJ, Jurlander J, Leffers H, et al. The CLLU1 expression level is a stable and inherent feature of the chronic lymphocytic leukemia clone. Leukemia. 2009;23:1182–1186. - PMC - PubMed
1. Cai J, Zhao R, Jiang H, Wang W. De novo origination of a new protein-coding gene in Saccharomyces cerevisiae. Genetics. 2008;179:487–496. - PMC - PubMed

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information