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Randomized Controlled Trial
. 2010 Jun;30(8):1005-15.
doi: 10.1007/s00296-009-1086-1. Epub 2009 Oct 2.

Patient-reported-outcomes in subjects with painful lumbar or cervical radiculopathy treated with pregabalin: evidence from medical practice in primary care settings

María Teresa Saldaña  1 , Ana Navarro, Concepción Pérez, Xavier Masramón, Javier Rejas
Affiliations
Randomized Controlled Trial

Patient-reported-outcomes in subjects with painful lumbar or cervical radiculopathy treated with pregabalin: evidence from medical practice in primary care settings

María Teresa Saldaña et al. Rheumatol Int. 2010 Jun.

Abstract

The objective of this study was to evaluate the effect of pregabalin in painful cervical or lumbosacral radiculopathy treated in Primary Care settings under routine clinical practice. An observational, prospective 12-week secondary analysis was carried-out. Male and female above 18 years, naïve to PGB, with refractory chronic pain secondary to cervical/lumbosacral radiculopathy were enrolled. SF-MPQ, Sheehan Disability Inventory, MOS Sleep Scale, Hospital Anxiety and Depression Scale and the EQ-5D were administered. A total of 490 (34%) patients were prescribed PGB-monotherapy, 702 (48%) received PGB add-on, and 159 (11%) were administered non-PGB drugs. After 12 weeks, significant improvements in pain, associated symptoms of anxiety, depression and sleep disturbances, general health; and level of disability were observed in the three groups, being significantly greater in PGB groups. In routine medical practice, monotherapy or add-on pregabalin is associated with substantial pain alleviation and associated symptoms improvements in painful cervical or lumbosacral radiculopathy.

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Conflict of interest statement

One of the authors of this study, Javier Rejas, is an employee of Pfizer Spain, which is the entity funding this project. Mª Teresa Saldaña, Ana Navarro, and Concepción Pérez have received honoraries from Pfizer Spain.

Figures

Fig. 1
Fig. 1
Patient disposition
Fig. 2
Fig. 2
Mean weekly change in pain intensity as scored by the VAS of the SF-MPQ
Fig. 3
Fig. 3
Mean weekly change in health status as scored by the VAS of the EQ-5D
See this image and copyright information in PMC

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