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. 2009 Oct 28;131(42):15078-9.
doi: 10.1021/ja904670x.

Vitamin B(12) and redox homeostasis: cob(II)alamin reacts with superoxide at rates approaching superoxide dismutase (SOD)

Edward Suarez-Moreira  1 , June Yun, Catherine S Birch, John H H Williams, Andrew McCaddon, Nicola E Brasch
Affiliations

Vitamin B(12) and redox homeostasis: cob(II)alamin reacts with superoxide at rates approaching superoxide dismutase (SOD)

Edward Suarez-Moreira et al. J Am Chem Soc. .

Abstract

We report a kinetic study of the reaction between superoxide and an important intracellular form of vitamin B(12), cob(II)alamin. Superoxide is implicated in the pathophysiology of many inflammatory diseases, whereas vitamin B(12) derivatives are often beneficial in their treatment. We found that cob(II)alamin reacts with superoxide at rates approaching those of superoxide dismutase itself, suggesting a probable mechanism by which vitamin B(12) protects against chronic inflammation and modulates redox homeostasis.

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