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. 2009 Nov 1;19(21):6119-21.
doi: 10.1016/j.bmcl.2009.09.022. Epub 2009 Sep 10.

Discovery of novel sphingosine kinase 1 inhibitors

Yibin Xiang  1 , Gary Asmussen, Michael Booker, Bradford Hirth, John L Kane Jr, Junkai Liao, Kevin D Noson, Christopher Yee
Affiliations

Discovery of novel sphingosine kinase 1 inhibitors

Yibin Xiang et al. Bioorg Med Chem Lett. .

Abstract

Sphingosine kinase 1 (SK1) is an important enzyme that regulates the balance between ceramide and sphingosine-1-phosphate (S1P). Potent and novel SK1 inhibitors (6ag, 9ab and 12aa) have been discovered through a series of modifications of sphingosine (1), the substrate of this enzyme.

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