Lymphotoxins: new targets for hepatocellular carcinoma
- PMID: 19800570
- PMCID: PMC3677157
- DOI: 10.1016/j.ccr.2009.09.012
Lymphotoxins: new targets for hepatocellular carcinoma
Abstract
In this issue of Cancer Cell, Haybaeck et al. unravel the role of lymphotoxin pathway in the development of hepatocellular carcinoma (HCC). Aberrant activation of this cascade in mice livers recapitulates the stages of fibrosis and inflammation that precedes human liver cancer, providing a novel family of potential therapeutic targets.
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Comment on
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A lymphotoxin-driven pathway to hepatocellular carcinoma.Cancer Cell. 2009 Oct 6;16(4):295-308. doi: 10.1016/j.ccr.2009.08.021. Cancer Cell. 2009. PMID: 19800575 Free PMC article.
References
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