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Comment
. 2009 Oct 6;16(4):272-3.
doi: 10.1016/j.ccr.2009.09.012.

Lymphotoxins: new targets for hepatocellular carcinoma

Affiliations
Comment

Lymphotoxins: new targets for hepatocellular carcinoma

Augusto Villanueva et al. Cancer Cell. .

Abstract

In this issue of Cancer Cell, Haybaeck et al. unravel the role of lymphotoxin pathway in the development of hepatocellular carcinoma (HCC). Aberrant activation of this cascade in mice livers recapitulates the stages of fibrosis and inflammation that precedes human liver cancer, providing a novel family of potential therapeutic targets.

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Figures

Figure 1
Figure 1. Potential targets of prevention and treatment of hepatocellular carcinoma (HCC)
Viral hepatitis and alcohol abuse are the main risk factors for developing chronic liver inflammation leading to advanced fibrosis and cirrhosis. Once advanced fibrosis has been established, evidence suggests the implication of inflammatory signals and growth factor cascades in the development of HCC. In this setting, chemoprevention strategies are expected to target key pro-oncogenic molecules. In established HCC, the molecular classification of the tumors would allow targeting specific pathways and oncogenic loops in a more personalized manner.

Comment on

  • A lymphotoxin-driven pathway to hepatocellular carcinoma.
    Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M. Haybaeck J, et al. Cancer Cell. 2009 Oct 6;16(4):295-308. doi: 10.1016/j.ccr.2009.08.021. Cancer Cell. 2009. PMID: 19800575 Free PMC article.

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