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Randomized Controlled Trial
. 2009 Oct;14(4):375-80.
doi: 10.1111/j.1542-474X.2009.00329.x.

Electrophysiologic characteristics of wide QRS complexes during pharmacologic termination of sustained supraventricular tachycardias with verapamil and adenosine: observations from electrophysiologic study

Cengizhan Türkoğlu  1 , Muzaffer Oztürk, Farid Aliyev, Inci Firatli, Nilgün Incesoy
Affiliations
Randomized Controlled Trial

Electrophysiologic characteristics of wide QRS complexes during pharmacologic termination of sustained supraventricular tachycardias with verapamil and adenosine: observations from electrophysiologic study

Cengizhan Türkoğlu et al. Ann Noninvasive Electrocardiol. 2009 Oct.

Abstract

Background: In this study we evaluate wide QRS complexes observed during pharmacologic termination of supraventricular tachycardias.

Methods: Patients with supraventricular tachycardia, undergoing electrophysiologic study were enrolled. 12 mg of adenosine or 10 mg of verapamil were administered during tachycardia, under continuous monitoring of intaracardiac and surface electrocardiograms. Electrocardiographic features of ventricular ectopy were noted.

Results: Seventy-four patients were enrolled. 48 patients were randomized to adenosine and 26 to verapamil. Five different appearance patterns of ventricular ectopy were observed during termination of tachycardias. All wide QRS complexes were of ventricular origin and all of them were observed during the termination of tachycardia. Adenosine more frequently resulted in appearance of ventricular beats (15.4% vs 41.7%, P = 0.003), and this was more frequently observed in patients with atrioventricular nodal reentrant tachycardia. Patients with ventricular beats were younger than those without, in both, verapamil (47.5 +/- 15.6 vs 65.0 +/- 8.8 years, P = 0.04) and adenosine (40.9 +/- 13.8 vs 49.7 +/- 16.8, P = 0.03) groups. Left bundle branch block (LBBB)/superior axis morphology was most frequent morphology in adenosine group (55%). Two of 4 patients in verapamil group displayed LBBB/inferior axis QRS morphology and another 2 patients displayed LBBB/superior axis morphology.

Conclusions: Noncatheter induced, five different appearance patterns and four distinct morphologies of ventricular origin were observed. Most of them do not directly terminate tachycardia, but are associated with its termination and are not observed in ongoing tachycardia.

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Figures

Figure 1
Figure 1
All five various appearance patterns of ventricular beats are presented above. (A) Type A; (B) Type B; (C) Type C; (D) Type D; (E) Combined Type B and E; (F) Combined Type D and E. (see text for explanation).
See this image and copyright information in PMC

References

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