Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990;39(1):17-9.
doi: 10.1007/BF02657050.

Pharmacology of the hypothermic response to 5-HT1A receptor activation in humans

K P Lesch  1 , B Poten, K Söhnle, H M Schulte
Affiliations

Pharmacology of the hypothermic response to 5-HT1A receptor activation in humans

K P Lesch et al. Eur J Clin Pharmacol. 1990.

Abstract

The selective 5-HT1A receptor ligand ipsapirone (IPS) caused dose-related hypothermia in humans. The response was attenuated by the nonselective 5-HT1/2 receptor antagonist metergoline and was completely antagonized by the nonselective beta-adrenoceptor antagonist pindolol, which interacts stereoselectively with the 5-HT1A receptor. The selective beta 1-adrenergic antagonist betaxolol had no effect. The findings indicate that IPS-induced hypothermia specifically involves activation of (presynaptic) 5-HT1A receptors. Therefore, the hypothermic response to IPS may provide a convenient in vivo paradigma to assess the function of the presynaptic 5-HT receptor in affective disorders and its involvement in the effects of psychotropic drugs.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Naunyn Schmiedebergs Arch Pharmacol. 1985 May;329(3):211-5 - PubMed
    1. Brain Res Bull. 1984 Jun;12(6):741-4 - PubMed
    1. Pharmacol Biochem Behav. 1988 Jun;30(2):451-6 - PubMed
    1. Trends Neurosci. 1988 Nov;11(11):496-500 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1986 Jan;332(1):1-7 - PubMed

LinkOut - more resources