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Review
. 1990 Oct;6(10):323-9.
doi: 10.1016/0168-9525(90)90253-3.

The structure of the homeodomain and its functional implications

W J Gehring  1 , M Müller, M Affolter, A Percival-Smith, M Billeter, Y Q Qian, G Otting, K Wüthrich
Affiliations
Review

The structure of the homeodomain and its functional implications

W J Gehring et al. Trends Genet. 1990 Oct.

Abstract

The three-dimensional structure of the homeodomain, as determined by nuclear magnetic resonance spectroscopy, reveals the presence of a helix-turn-helix motif, similar to the one found in prokaryotic gene regulatory proteins. Isolated homeodomains bind with high affinity to specific DNA sequences. Thus, the structure-function relationship is highly conserved in evolution.

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