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Comment
. 2009 Oct;10(4):241-2.
doi: 10.1016/j.cmet.2009.09.003.

Does hypothalamic inflammation cause obesity?

Brent E Wisse  1 , Michael W Schwartz
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Free article
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Does hypothalamic inflammation cause obesity?

Brent E Wisse et al. Cell Metab. 2009 Oct.
Free article

Abstract

Obesity-induced inflammation causes cellular resistance to both insulin and leptin. In this issue, Brüning and colleagues (Kleinridders et al., 2009) add to growing evidence that this response occurs in the hypothalamus, as well as in peripheral tissues, which helps to explain how high-fat feeding induces a gradual increase in defended body weight.

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