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. 2010 Jan;33(1):95-7.
doi: 10.2337/dc09-1227. Epub 2009 Oct 6.

Comparison of A1C and fasting glucose criteria to diagnose diabetes among U.S. adults

April P Carson  1 , Kristi Reynolds, Vivian A Fonseca, Paul Muntner
Affiliations

Comparison of A1C and fasting glucose criteria to diagnose diabetes among U.S. adults

April P Carson et al. Diabetes Care. 2010 Jan.

Abstract

Objective: To compare A1C and fasting glucose for the diagnosis of diabetes among U.S. adults.

Research design and methods: This study included 6,890 adults (> or =20 years of age) from the 1999-2006 National Health and Nutrition Examination Survey without a self-reported history of diabetes who had fasted > or =9 h. A1C > or =6.5% and fasting glucose > or =126 mg/dl were used, separately, to define diabetes.

Results: Overall, 1.8% of U.S. adults had A1C > or =6.5% and fasting glucose > or =126 mg/dl, 0.5% had A1C > or =6.5% and fasting glucose <126 mg/dl, and 1.8% had A1C <6.5% and fasting glucose > or =126 mg/dl. Compared with individuals with A1C <6.5% and fasting glucose > or =126 mg/dl, individuals with A1C > or =6.5% and fasting glucose <126 mg/dl were younger, more likely to be non-Hispanic black, had lower Hb levels, and had higher C-reactive protein.

Conclusions: A1C > or =6.5% demonstrates reasonable agreement with fasting glucose for diagnosing diabetes among U.S. adults.

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