mTOR signaling at a glance

doi:10.1242/jcs.051011

Review

. 2009 Oct 15;122(Pt 20):3589-94.

doi: 10.1242/jcs.051011.

mTOR signaling at a glance

Mathieu Laplante¹, David M Sabatini

Affiliations

PMID: 19812304
PMCID: PMC2758797
DOI: 10.1242/jcs.051011

Review

mTOR signaling at a glance

Mathieu Laplante et al. J Cell Sci. 2009.

. 2009 Oct 15;122(Pt 20):3589-94.

doi: 10.1242/jcs.051011.

Authors

Mathieu Laplante¹, David M Sabatini

Affiliation

¹ Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.

PMID: 19812304
PMCID: PMC2758797
DOI: 10.1242/jcs.051011

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References

1. Arsham, A. M., Howell, J. J. and Simon, M. C. (2003). A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J. Biol. Chem. 278, 29655-29660. - PubMed
1. Bentzinger, C. F., Romanino, K., Cloetta, D., Lin, S., Mascarenhas, J. B., Oliveri, F., Xia, J., Casanova, E., Costa, C. F., Brink, M. et al. (2008). Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab. 8, 411-424. - PubMed
1. Bernardi, R., Guernah, I., Jin, D., Grisendi, S., Alimonti, A., Teruya-Feldstein, J., Cordon-Cardo, C., Simon, M. C., Rafii, S. and Pandolfi, P. P. (2006). PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature 442, 779-785. - PubMed
1. Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W. and Kaelin, W. G., Jr (2004). Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 18, 2893-2904. - PMC - PubMed
1. Calnan, D. R. and Brunet, A. (2008). The FoxO code. Oncogene 27, 2276-2288. - PubMed

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[1] Arsham, A. M., Howell, J. J. and Simon, M. C. (2003). A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J. Biol. Chem. 278, 29655-29660. - PubMed

[2] Arsham, A. M., Howell, J. J. and Simon, M. C. (2003). A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets. J. Biol. Chem. 278, 29655-29660. - PubMed

[3] Bentzinger, C. F., Romanino, K., Cloetta, D., Lin, S., Mascarenhas, J. B., Oliveri, F., Xia, J., Casanova, E., Costa, C. F., Brink, M. et al. (2008). Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab. 8, 411-424. - PubMed

[4] Bentzinger, C. F., Romanino, K., Cloetta, D., Lin, S., Mascarenhas, J. B., Oliveri, F., Xia, J., Casanova, E., Costa, C. F., Brink, M. et al. (2008). Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metab. 8, 411-424. - PubMed

[5] Bernardi, R., Guernah, I., Jin, D., Grisendi, S., Alimonti, A., Teruya-Feldstein, J., Cordon-Cardo, C., Simon, M. C., Rafii, S. and Pandolfi, P. P. (2006). PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature 442, 779-785. - PubMed

[6] Bernardi, R., Guernah, I., Jin, D., Grisendi, S., Alimonti, A., Teruya-Feldstein, J., Cordon-Cardo, C., Simon, M. C., Rafii, S. and Pandolfi, P. P. (2006). PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature 442, 779-785. - PubMed

[7] Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W. and Kaelin, W. G., Jr (2004). Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 18, 2893-2904. - PMC - PubMed

[8] Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W. and Kaelin, W. G., Jr (2004). Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 18, 2893-2904. - PMC - PubMed

[9] Calnan, D. R. and Brunet, A. (2008). The FoxO code. Oncogene 27, 2276-2288. - PubMed

[10] Calnan, D. R. and Brunet, A. (2008). The FoxO code. Oncogene 27, 2276-2288. - PubMed

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mTOR signaling at a glance

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mTOR signaling at a glance

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