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Comment

CCL3L1 and HIV/AIDS susceptibility

Thomas J Urban et al. Nat Med. 2009 Oct.
No abstract available

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Figures

Figure 1
Figure 1
(a and b) Distribution of CCL3L1 copy number in HIV-infected individuals of recent (a) European or (b) African ancestry. Median CCL3L1 copy number was 2 in patients of recent European descent and 4 in patients of recent African descent. (c and d) Relationship between HIV viral load at setpoint and CCL3L1 copy number among patients of recent European (c) or African (d) ancestry. Linear regression of HIV viral load at setpoint on CCL3L1 copy number showed no significant effect of CCL3L1 dose (European: r2 = 0.0006, P = 0.14; African: r2 = 0.0022, P = 0.27). (e and f) Relationship among CCL3L1 copy number, CCL3L1 mRNA expression, and viral load at set point. Specific expression of CCL3L1 mRNA in CD4+ T cells was determined using the Illumina WG-6 v3 expression array. CCL3L1 expression in CD4+ T lymphocytes showed a strong correlation with copy number, but was not associated with viremia.
See this image and copyright information in PMC

Comment in

  • CCL3L1 and HIV/AIDS susceptibility.
    Bhattacharya T, Stanton J, Kim EY, Kunstman KJ, Phair JP, Jacobson LP, Wolinsky SM. Bhattacharya T, et al. Nat Med. 2009 Oct;15(10):1112-5. doi: 10.1038/nm1009-1112. Nat Med. 2009. PMID: 19812561 No abstract available.
  • Reply to: "Experimental aspects of copy number variant assays at CCL3L1".
    He W, Kulkarni H, Castiblanco J, Shimizu C, Aluyen U, Maldonado R, Carrillo A, Griffin M, Lipsitt A, Beachy L, Shostakovich-Koretskaya L, Mangano A, Sen L, Nibbs RJ, Tiemessen CT, Bolivar H, Bamshad MJ, Clark RA, Burns JC, Dolan MJ, Ahuja SK. He W, et al. Nat Med. 2009 Oct;15(10):1117-20. doi: 10.1038/nm1009-1117. Nat Med. 2009. PMID: 19812563 No abstract available.
  • Gene copy number: learning to count past two.
    Shrestha S, Tang J, Kaslow RA. Shrestha S, et al. Nat Med. 2009 Oct;15(10):1127-9. doi: 10.1038/nm1009-1127. Nat Med. 2009. PMID: 19812568 No abstract available.

Comment on

References

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