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. 2009 Oct;15(10):1115-7.
doi: 10.1038/nm1009-1115.

Experimental aspects of copy number variant assays at CCL3L1

Sarah F Field, Joanna M M Howson, Lisa M Maier, Susan Walker, Neil M Walker, Deborah J Smyth, John A L Armour, David G Clayton, John A Todd

Experimental aspects of copy number variant assays at CCL3L1

Sarah F Field et al. Nat Med. 2009 Oct.
No abstract available

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Figures

Figure 1
Figure 1
Histograms of the frequency of the chromosome 17q12 CNV measure obtained using PRT and QPCR assays. Ratios of the CNV (CCL3L1, CCL4L1, LTR17) versus the reference (paralogous loci CCL3, CCL4, LTR10 for PRT and the haemoglobin beta gene for QPCR) that are used to assign copy numbers, either by rounding the data to the nearest integer or by using k-means clustering, are presented. (a) Assay ratio (copies) of CCL3L1 obtained using PRT in 3,860 cases and (b) 4,084 controls. (c) Assay ratios (copies) of CCL4L1 obtained using PRT in 4,041 cases and (d) 4,318 controls. (e) Assay ratios (copies) of the LTR on chr17q12 obtained using PRT in 4,044 cases and (f) in 4,266 controls. (g) Assay ratios (copies) of CCL3L1 obtained using QPCR in 3,362 cases and (h) in 3,983 controls.
See this image and copyright information in PMC

Comment in

  • Reply to: "Experimental aspects of copy number variant assays at CCL3L1".
    He W, Kulkarni H, Castiblanco J, Shimizu C, Aluyen U, Maldonado R, Carrillo A, Griffin M, Lipsitt A, Beachy L, Shostakovich-Koretskaya L, Mangano A, Sen L, Nibbs RJ, Tiemessen CT, Bolivar H, Bamshad MJ, Clark RA, Burns JC, Dolan MJ, Ahuja SK. He W, et al. Nat Med. 2009 Oct;15(10):1117-20. doi: 10.1038/nm1009-1117. Nat Med. 2009. PMID: 19812563 No abstract available.
  • Gene copy number: learning to count past two.
    Shrestha S, Tang J, Kaslow RA. Shrestha S, et al. Nat Med. 2009 Oct;15(10):1127-9. doi: 10.1038/nm1009-1127. Nat Med. 2009. PMID: 19812568 No abstract available.

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