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Review
. 1990:603:1-17; discussion 18.
doi: 10.1111/j.1749-6632.1990.tb37657.x.

Overview. Purinergic mechanisms

G Burnstock  1
Affiliations
Review

Overview. Purinergic mechanisms

G Burnstock. Ann N Y Acad Sci. 1990.

Abstract

An overview of the history of studies of the biological actions of extracellular ATP is presented. The basis of the subdivision of receptors for purines into P1-purinoceptors for adenosine and P2-purinoceptors for ATP and ADP are considered, as well as the recent proposal for subdivision of the ATP receptors into P2X-, P2Y-, P2Z-, and P2T- purinoceptor subtypes. These purinoceptor subtypes are discussed with respect to their transduction mechanisms, their distribution, and their physiological roles, including their roles in cotransmission and neuromodulation.

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