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. 2009 Nov 5;11(21):5078-81.
doi: 10.1021/ol902085k.

A versatile new synthetic route to 1N-hydroxyindazoles

Fredrik Lehmann  1 , Tobias Koolmeister, Luke R Odell, Martin Scobie
Affiliations

A versatile new synthetic route to 1N-hydroxyindazoles

Fredrik Lehmann et al. Org Lett. .

Abstract

A new and versatile cyclization reaction affording rare 1N-hydroxyindazoles is presented. Treatment of 2-nitrobenzylamines with methanolic sodium hydroxide furnishes 1N-hydroxyindazoles regioselectively and in high yield. The reaction tolerates a range of functional groups and electronic effects.

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