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. 2009 Nov;94(11):1624-5.
doi: 10.3324/haematol.2009.012971. Epub 2009 Oct 8.

Chronic hemolytic anemia due to novel alpha-globin chain variants: critical location of the mutation within the gene sequence for a dominant effect

Claude Préhu, Kamran Moradkhani, Jean Riou, Michel Bahuau, Pierre Launay, Natacha Martin, Henri Wajcman, Michel Goossens, Frédéric Galactéros

Chronic hemolytic anemia due to novel alpha-globin chain variants: critical location of the mutation within the gene sequence for a dominant effect

Claude Préhu et al. Haematologica. 2009 Nov.
No abstract available

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Figures

Figure 1.
Figure 1.
Nucleotide sequence of exon 3 in wild-type and mutated α globin genes, with resulting protein sequences. (A) Wild-type sequences of exon 3 in the α gene showing the potential stops (bold and underlined) that may result from FS. (B) In Hb Fez, the 3rd nucleotide of codon 131 is deleted, leading to FS and occurrence of a stop at CD132. (C) In Hb Senlis, deletion of a C within CD134 leads to a stop at CD136 and to a Cys as the outermost residue of the C-terminus.
See this image and copyright information in PMC

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