Pharmacologic therapy of non-alcoholic steatohepatitis
- PMID: 19818312
- DOI: 10.1016/j.cld.2009.07.001
Pharmacologic therapy of non-alcoholic steatohepatitis
Abstract
Specific therapy for non-alcoholic steatohepatitis (NASH) is needed because of the potential severity of this liver disease. NASH is a recognized cause of cryptogenic cirrhosis and, increasingly, of hepatocellular carcinoma. Therefore, there is an unmet medical need for the therapy of NASH. This article discusses this therapy, with particular emphasis on pharmacologic therapy.
Similar articles
-
Review article: Drug therapy for non-alcoholic fatty liver disease.Aliment Pharmacol Ther. 2006 Jan 15;23(2):207-15. doi: 10.1111/j.1365-2036.2006.02751.x. Aliment Pharmacol Ther. 2006. PMID: 16393299 Review.
-
[Non-alcoholic steatohepatitis].Rev Gastroenterol Mex. 2002 Apr-Jun;67(2):118-25. Rev Gastroenterol Mex. 2002. PMID: 12214335 Review. Spanish.
-
Nonalcoholic fatty liver disease.Clin Liver Dis. 2012 May;16(2):397-419. doi: 10.1016/j.cld.2012.03.005. Clin Liver Dis. 2012. PMID: 22541706 Review.
-
Non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH): treatment.Best Pract Res Clin Gastroenterol. 2004 Dec;18(6):1105-16. doi: 10.1016/j.bpg.2004.06.025. Best Pract Res Clin Gastroenterol. 2004. PMID: 15561641 Review.
-
Current Pharmacologic Therapy for Nonalcoholic Fatty Liver Disease.Clin Liver Dis. 2016 May;20(2):351-64. doi: 10.1016/j.cld.2015.10.009. Epub 2016 Feb 19. Clin Liver Dis. 2016. PMID: 27063274 Review.
Cited by
-
A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis.Hepatology. 2012 Feb;55(2):419-28. doi: 10.1002/hep.24747. Epub 2011 Dec 14. Hepatology. 2012. PMID: 22006541 Free PMC article. Clinical Trial.
-
Pharmacologic effects of 2-methoxyestradiol on angiotensin type 1 receptor down-regulation in rat liver epithelial and aortic smooth muscle cells.Gend Med. 2012 Apr;9(2):76-93. doi: 10.1016/j.genm.2012.01.008. Epub 2012 Feb 25. Gend Med. 2012. PMID: 22366193 Free PMC article.
-
Interplay between EGR1 and SP1 is critical for 13-cis retinoic acid-mediated transcriptional repression of angiotensin type 1A receptor.J Mol Endocrinol. 2013 Apr 23;50(3):361-74. doi: 10.1530/JME-12-0154. Print 2013 Jun. J Mol Endocrinol. 2013. PMID: 23475749 Free PMC article.
-
Safety and impact on cardiovascular events of long-term multifactorial treatment in patients with metabolic syndrome and abnormal liver function tests: a post hoc analysis of the randomised ATTEMPT study.Arch Med Sci. 2011 Oct;7(5):796-805. doi: 10.5114/aoms.2011.25554. Epub 2011 Nov 8. Arch Med Sci. 2011. PMID: 22291824 Free PMC article.
-
Practical management of the increasing burden of non-alcoholic fatty liver disease.Frontline Gastroenterol. 2010 Oct;1(3):149-155. doi: 10.1136/fg.2009.000935. Epub 2010 Sep 23. Frontline Gastroenterol. 2010. PMID: 28839568 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources