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. 2009 Nov 15;19(22):6399-403.
doi: 10.1016/j.bmcl.2009.09.056. Epub 2009 Sep 19.

Imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1

Kristjan S Gudmundsson  1 , Sharon D Boggs, John G Catalano, Angilique Svolto, Andrew Spaltenstein, Michael Thomson, Pat Wheelan, Stephen Jenkinson
Affiliations

Imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV-1

Kristjan S Gudmundsson et al. Bioorg Med Chem Lett. .

Abstract

Synthesis of several novel imidazopyridine-5,6,7,8-tetrahydro-8-quinolinamine derivatives with potent activity against HIV are described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity and pharmacokinetics are highlighted. Several compounds with low nanomolar anti-HIV activity and oral bioavailability are described.

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