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Multicenter Study
. 2009 Nov;28(11):996-1001.
doi: 10.1097/INF.0b013e3181a78348.

Determinants of vaccine immunity in the cohort of human immunodeficiency virus-infected children living in Switzerland

Catherine Myers  1 , Klara M Posfay-Barbe, Christoph Aebi, Jean-Jacques Cheseaux, Christian Kind, Christoph Rudin, David Nadal, Claire-Anne Siegrist; Pediatric Infectious Disease Group of Switzerland (PIGS); Swiss Mother and Child HIV Cohort Study (MoCHIV)
Collaborators, Affiliations
Multicenter Study

Determinants of vaccine immunity in the cohort of human immunodeficiency virus-infected children living in Switzerland

Catherine Myers et al. Pediatr Infect Dis J. 2009 Nov.

Abstract

Background: Human immunodeficiency virus (HIV)-infected children are at increased risk of infections caused by vaccine preventable pathogens, and specific immunization recommendations have been issued.

Methods: A prospective national multicenter study assessed how these recommendations are followed in Switzerland and how immunization history correlates with vaccine immunity.

Results: Among 87 HIV-infected children (mean age: 11.1 years) followed in the 5 Swiss university hospitals and 1 regional hospital, most (76%) had CD4 T cells >25%, were receiving highly active antiretroviral treatment (79%) and had undetectable viral load (60%). Immunization coverage was lower than in the general population and many lacked serum antibodies to vaccine-preventable pathogens, including measles (54%), varicella (39%), and hepatitis B (65%). The presence of vaccine antibodies correlated most significantly with having an up-to-date immunization history (P<0.05). An up-to-date immunization history was not related to age, immunologic stage, or viremia but to the referral medical center.

Conclusions: All pediatricians in charge of HIV-infected children are urged to identify missing immunizations in this high-risk population.

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