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. 2010 Jan;148(1):115-8.
doi: 10.1111/j.1365-2141.2009.07945.x. Epub 2009 Oct 11.

IRF4 is modulated by CD40L and by apoptotic and anti-proliferative signals in Hodgkin lymphoma

Donatella Aldinucci  1 , Barbara Rapana', Karin Olivo, Debora Lorenzon, Annunziata Gloghini, Alfonso Colombatti, Antonino Carbone
Affiliations

IRF4 is modulated by CD40L and by apoptotic and anti-proliferative signals in Hodgkin lymphoma

Donatella Aldinucci et al. Br J Haematol. 2010 Jan.

Abstract

The effects of proliferative, apoptotic and anti-proliferative stimuli on interferon regulatory factor 4 (IRF4) expression by Reed-Sternberg (RS) cells were analysed using a panel of Hodgkin lymphoma (HL)-derived cell lines. IRF4 expressed by HL cells was consistently upregulated after CD40 engagement; IRF4 was downregulated by agonistic anti-CD95 antibodies in the FAS-sensitive HDLM-2 cells and after treatment with Adriamycin and Dacarbazine, two chemotherapic agents commonly used for HL treatment. These results demonstrated, for the first time, that IRF4 was up-modulated by CD40 engagement, and down-modulated by apoptotic and anti-proliferative signals, suggesting an involvement of IRF4 also in HL pathobiology.

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