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Editorial
. 2009 Oct 27;120(17):1654-6.
doi: 10.1161/CIRCULATIONAHA.109.905356. Epub 2009 Oct 12.

New insights into cardiac aging

Anthony J Muslin
Editorial

New insights into cardiac aging

Anthony J Muslin. Circulation. .
No abstract available

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Figures

Figure
Figure
A simplified model of insulin-stimulated cardiac aging. Caloric intake results in pancreatic insulin secretion and insulin binds to cardiomyocyte cell surface receptors. Insulin binding to cognate receptors results in activation of an intracellular signaling cascade that includes IRS-1, PI3K, PDK1 and Akt family members. Akt proteins phosphorylate and inhibit FoxO transcription factors by promoting their nuclear exclusion. Akt proteins also phosphorylate and inhibit TSC2, ultimately leading to activation of TOR complex 1 via Rheb. FoxO transcription factors promote autophagy whereas TORC1 inhibits autophagy. Autophagy prevents lipofuscin accumulation and aging of the myocardium.
See this image and copyright information in PMC

Comment on

  • Suppression of phosphoinositide 3-kinase prevents cardiac aging in mice.
    Inuzuka Y, Okuda J, Kawashima T, Kato T, Niizuma S, Tamaki Y, Iwanaga Y, Yoshida Y, Kosugi R, Watanabe-Maeda K, Machida Y, Tsuji S, Aburatani H, Izumi T, Kita T, Shioi T. Inuzuka Y, et al. Circulation. 2009 Oct 27;120(17):1695-703. doi: 10.1161/CIRCULATIONAHA.109.871137. Epub 2009 Oct 12. Circulation. 2009. PMID: 19822807

References

    1. Weindruch R, Walford RL, Fligiel S, Guthrie D. The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J Nutr. 1986:641–654. - PubMed
    1. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G. Daf-2, an insulin receptor-like gene that regulates longevity and diapauses in Caenorhabditis elegans. Science. 1997;277:942–946. - PubMed
    1. Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M. Suppression of aging in mice by the hormone Klotho. Science. 2005;309:1829–1833. - PMC - PubMed
    1. Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science. 2003;299:572–574. - PubMed
    1. Morris JZ, Tissnebaum HA, Ruvkun G. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapose in Caenorhabditis elegans. Nature. 1996;382:536–539. - PubMed

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