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. 1990 Nov;42(11):802-3.
doi: 10.1111/j.2042-7158.1990.tb07026.x.

The effect of cigarette smoke on the plasma piroxicam concentrations in rats

F Lermioğlu  1 , T Berkan, M Yasa, Z Kerry, C Yalçinkaya, A Ozer
Affiliations

The effect of cigarette smoke on the plasma piroxicam concentrations in rats

F Lermioğlu et al. J Pharm Pharmacol. 1990 Nov.

Abstract

The plasma concentration of unchanged piroxicam has been determined at 15, 30, 60 and 90 min after 10 mg kg-1 oral administration of the drug to rats exposed to cigarette smoke or pretreated with phenobarbitone, 3,4-benzpyrene or ethanol. Plasma piroxicam concentrations decreased in rats pretreated with phenobarbitone, 3,4-benzpyrene and ethanol and in rats 24 h after exposure to cigarette smoke.

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