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. 2009 Oct 14;15(38):4770-4.
doi: 10.3748/wjg.15.4770.

Carotid lesions in outpatients with nonalcoholic fatty liver disease

Stefano Ramilli  1 , Stefano Pretolani, Antonio Muscari, Barbara Pacelli, Vincenzo Arienti
Affiliations

Carotid lesions in outpatients with nonalcoholic fatty liver disease

Stefano Ramilli et al. World J Gastroenterol. .

Abstract

Aim: To ascertain whether carotid lesions are more prevalent in outpatients with incidental findings of nonalcoholic fatty liver disease (NAFLD) at abdominal ultrasound (US).

Methods: One hundred and fifty-four consecutive outpatients (age range 24-90 years, both sexes) referred by general practitioners for abdominal US, and drinking less than 20 g alcohol/day, underwent carotid US for an assessment of carotid intima-media thickness (c-IMT) and carotid plaque prevalence. Hepatic steatosis, visceral fat thickness and subcutaneous fat thickness were also assessed at ultrasonography.

Results: Higher c-IMT values were found in the presence of NAFLD (90 patients), even after adjustment for indices of general and abdominal obesity and for the principal cardiovascular risk factors (0.84 +/- 0.10 mm vs 0.71 +/- 0.10 mm, P < 0.001). The prevalence of carotid plaques was 57.8% in the patients with NAFLD vs 37.5% in the patients without this condition (P = 0.02). The adjusted relative risk of having carotid plaques for patients with NAFLD was 1.85 (95% CI: 1.33-2.57, P < 0.001).

Conclusion: An incidental finding of hepatic steatosis may suggest the presence of silent carotid atherosclerotic lesions.

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