[Role of alpha- and beta-adrenoreceptors in catecholamine regulation of the natriuretic function of the kidneys in rats]

Abstract

In acute tests set up on rats subject to investigations was the significance of alpha- and beta-adrenoreceptors in the mechanism of the catecholamines influence on the natriuretic function of the rats' kidneys. Phentolamine did not obstruct the stimulating action of epinephrine on the tubular reabsorption of sodium, but perverted its inhibitory effect on the glomerular filtration. Inderal did not affect the glomerular action of epinephrine, but fully prevented its effect on reabsorption of sodium in the tubules of the kidney. When used in a dose failing to produce any significant changes in the systemic arterial pressure isopropylnorepinephrine increased glomerular filtration, but inhibited excretion of sodium, augmenting its tubular reabsorption. The resulting implication is that alpha-adrenoreceptors participate in the mechanism of the catecholamines regulation of the intrarenal hemodynamics, whereas beta-adrenoreceptors play the part of mediating their activating influence on the tubular transport of sodium.