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Review
. 2009 Oct;109(10):4568-79.
doi: 10.1021/cr900052g.

Living with iron (and oxygen): questions and answers about iron homeostasis

Elizabeth C Theil  1 , Dixie J Goss
Affiliations
Review

Living with iron (and oxygen): questions and answers about iron homeostasis

Elizabeth C Theil et al. Chem Rev. 2009 Oct.
No abstract available

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Figures

Figure 1
Figure 1
Dual regulation of mRNA and DNA by heme–repressor (bach 1 or IRP) interactions. Luciferase activity, encoded in plasmids under the control of the human ferritin L DNA–ARE promoter or the human ferritin L DNA–ARE promoter plus the mRNA–IRE 5′UTR regulator (promoter), was measured in HeLa cells as described in ref . Antioxidant response inducers: Fe-PP, Fe- protoporphyrin IX (heme); HQ, t-butylhydroquinone; ITC, 4-methylsulfinylbutyl isothiocyanate (sulforaphane; iron inducer is ferric citrate (1:10)), and the data are from ref with the error as the standard deviation.
Figure 2
Figure 2
Structure of an IRE RNA and complexed with IRP1. Data are modified from ref ; apo-IRP has not been crystallized to date and appears to have disordered regions. The ribbon diagram of the IRE-RNA used PDB file 2IPY.
Figure 3
Figure 3
Model for IRE/IRP-regulated translational control. Structures incorporated into the illustration are taken from IRE-RNA/IRP complex, ribosome, ferritin subunit, and ferritin nanocage.
Figure 4
Figure 4
Links between oxygen and iron homeostasis through ferritin: The Fe/O feedback loop. Frt) ferritin; IRP) iron regulatory protein, binds ferritin IRE–RNA; IRE) iron responsive element; bach-1) a transcription factor that binds ARE–DNA; ARE) antioxidant response element.
See this image and copyright information in PMC

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