Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2009 Oct 20;106(42):17609-10.
doi: 10.1073/pnas.0910634106. Epub 2009 Oct 13.

One billion years of p53/p63/p73 evolution

Vladimir A Belyi  1 , Arnold J Levine
Affiliations
Comment

One billion years of p53/p63/p73 evolution

Vladimir A Belyi et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
The domain structure of the p53 family proteins. (A) The domain organization of human p53, p63, and p73 along with the p63/p73 ancestor proteins from Drosophila melanogaster and Caenorhabditis elegans. The percentage of identity of the amino acids and their position in the domain are given for both the DNA-binding domain and the oligomeric domain. (B) The structure of the oligomeric domain of p73 from ref. . The H-2 helix stabilizes this p73 tetramer and is absent from the p53 tetramer. p63 and p73 are more closely related to each other than to p53 based on the primary, secondary, tertiary, and quaternary structures of both the DNA-binding domains and the oligomerization domains.
See this image and copyright information in PMC

Comment on

References

    1. Joerger AC, et al. Structural evolution of p53, p63 and p73: Implications for heterotetramer formation. Proc Natl Acad Sci USA. 2009;106:17705–17710. - PMC - PubMed
    1. Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature. 2000;408:307–310. - PubMed
    1. Malkin D, et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science. 1990;250:1233–1238. - PubMed
    1. Yang A, et al. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature. 1999;398:714–718. - PubMed
    1. Celli J, et al. Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome. Cell. 1999;99:143–153. - PubMed

MeSH terms