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. 2009 Dec 1;101(11):1919-24.
doi: 10.1038/sj.bjc.6605373. Epub 2009 Oct 13.

Brain metastases admissions in Sweden between 1987 and 2006

K E Smedby  1 , L Brandt, M L Bäcklund, P Blomqvist
Affiliations

Brain metastases admissions in Sweden between 1987 and 2006

K E Smedby et al. Br J Cancer. .

Abstract

Background: Brain metastases (BM) constitute the most common intracranial tumours and are associated with considerable morbidity and mortality. Population-based studies of the epidemiology and time trends of BM are scarce.

Methods: A population-based cohort of patients admitted to hospital with BM in Sweden between 1987 and 2006 (n=15,517) was identified and linked to nationwide registers of cancer incidence and death. Primary cancer types were assessed and time to hospitalisation and death was computed.

Results: The annual age-adjusted incidence rate of hospitalisation for BM doubled from 7 to 14 patients per 100,000 between 1987 and 2006. The most common primary tumours among women were lung (33%), breast (33%) and colorectal cancer (7%), and among men lung cancer (44%), malignant melanoma (12%) and colorectal cancer (9%). The increase was most evident for BM patients with lung cancer (both sexes) and breast cancer (women). Survival was short, with a median of 2.7 months. It varied little by cancer type and did not improve over calendar time.

Conclusion: The number of patients admitted with BM has increased rapidly in Sweden. In spite of recent improvements in the prognosis of common primary cancer types, any parallel improvement among patients with advanced cancer and BM is not indicated.

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Figures

Figure 1
Figure 1
(A) Brain metastases admissions in Sweden between 1987 and 2006: age-standardized* rate of patients admitted with BM per 100 000 persons and year. (B) Brain metastases admissions in Sweden between 1987 and 2006: age-standardized* rate of male patients admitted with BM per 100 000 persons and year. (C) Brain metastases admissions in Sweden between 1987 and 2006: age-standardized* rate of female patients admitted with BM per 100 000 persons and year. *The Swedish population in the year 1995 was used as the standard. †Included mainly cancer in the upper gastrointestinal tract, bladder and ear–nose–throat area.
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References

    1. Altundag K, Bondy ML, Mirza NQ, Kau SW, Broglio K, Hortobagyi GN, Rivera E (2007) Clinicopathologic characteristics and prognostic factors in 420 metastatic breast cancer patients with central nervous system metastasis. Cancer 110: 2640–2647 - PubMed
    1. Barlow L, Westergren K, Holmberg L, Talback M (2009) The completeness of the Swedish Cancer Register: a sample survey for year 1998. Acta Oncol 48: 27–33 - PubMed
    1. Barnholtz-Sloan JS, Sloan AE, Davis FG, Vigneau FD, Lai P, Sawaya RE (2004) Incidence proportions of brain metastases in patients diagnosed (1973–2001) in the Metropolitan Detroit Cancer Surveillance System. J Clin Oncol 22: 2865–2872 - PubMed
    1. Cancer Incidence in Sweden (1999) National Board of Health and Welfare. Official Statistics of Sweden. Health and Diseases 2001: 4. Published at: http://www.socialstyrelsen.se/publikationer2001/2001-42-4
    1. Cancer Incidence in Sweden (2007) National Board of Health and Welfare. Official Statistics of Sweden. Health and Diseases 2008: 11. Published at: http://www.socialstyrelsen.se/publikationer2008/2008-125-16