Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Jun;5(2):220-30.
doi: 10.1007/s11481-009-9178-y. Epub 2009 Oct 14.

Experimental autoimmune encephalomyelitis in the common marmoset, a bridge between rodent EAE and multiple sclerosis for immunotherapy development

Affiliations
Review

Experimental autoimmune encephalomyelitis in the common marmoset, a bridge between rodent EAE and multiple sclerosis for immunotherapy development

Yolanda S Kap et al. J Neuroimmune Pharmacol. 2010 Jun.

Abstract

The attrition rate of new drugs for central nervous system diseases including multiple sclerosis (MS) is very high. A widely recognized bottleneck in the selection of promising central nervous system drug candidates from the development pipeline is the lack of sufficiently predictive animal models. Here, we review how the experimental autoimmune encephalomyelitis (EAE) model in the Neotropical primate "common marmoset" can help to bridge the gap between rodent EAE models and MS. The EAE model in the marmoset closely resembles MS in the clinical as well as pathological presentation and can be used for fundamental research into immunopathogenic mechanisms and for therapy development. We discuss recent insights arising from this model, both on novel therapeutics and immunopathogenesis.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Ann Neurol. 1995 Apr;37(4):519-30 - PubMed
    1. J Immunol. 2008 Feb 1;180(3):1326-37 - PubMed
    1. Acta Neurol Scand Suppl. 2006;183:48-50 - PubMed
    1. Ann Neurol. 2006 Jul;60(1):12-21 - PubMed
    1. Eur J Immunol. 1999 Oct;29(10):3140-7 - PubMed

MeSH terms

LinkOut - more resources