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Case Reports
. 2009 Sep-Oct;17(5):342-4.
doi: 10.3109/09273940903144705.

Vitreous metastases of primary cutaneous B-cell lymphoma

Deborah Y Chong  1 , Mark W Johnson, Defen Shen, Chi-Chao Chan, David G Callanan
Affiliations
Case Reports

Vitreous metastases of primary cutaneous B-cell lymphoma

Deborah Y Chong et al. Ocul Immunol Inflamm. 2009 Sep-Oct.

Abstract

Purpose: To describe two cases of vitreous metastases of primary cutaneous B-cell lymphoma (PCBCL).

Methods: Observational case series.

Results: A 73-year-old man and an 81-year-old woman, both with a history of PCBCL, diffuse large cell type, presented with decreased visual acuity due to vitritis. Both patients underwent vitreous biopsy that demonstrated B-cell lymphoma, large cell type, and confirmed metastases of cutaneous B-cell lymphoma to the vitreous.

Conclusion: PCBCL, diffuse large cell type, is a rare form of non-Hodgkin lymphoma that can metastasize to the vitreous without visible chorioretinal involvement.

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Conflict of interest statement

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Figures

FIGURE 1
FIGURE 1
(A) Fundus photograph of left eye at presentation. (B) Fundus photograph of left eye after diagnostic pars plana vitrectomy and completion of radiation treatment.
FIGURE 2
FIGURE 2
(A) Histopathology of skin biopsy showing anaplastic lymphoid cells with pleomorphic nuclei in mitosis (hematoxylin & eosin stain, 200×). (B) Cytology of vitreous biopsy showing atypical lymphoid cells containing large irregular nuclei, few reactive lymphocytes, and macrophages (Giemsa stain, 400×).
FIGURE 3
FIGURE 3
(A) Fundus photograph of right eye at presentation. (B) Fundus photograph of right eye after diagnostic pars plana vitrectomy and completion of radiation treatment.
FIGURE 4
FIGURE 4
PCR analyses of IgH gene rearrangements. PCR amplification of DNA from microdissected cells of the skin and vitreous specimens are positive using three primers for IgH genes. The PCR products of the skin and vitreous samples are identical.
See this image and copyright information in PMC

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