Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Nov;27(9):942-51.
doi: 10.3109/07357900902849632.

Vitamin D and non-Hodgkin lymphoma risk in adults: a review

Jennifer L Kelly  1 , Jonathan W Friedberg, Laura M Calvi, Edwin van Wijngaarden, Susan G Fisher
Affiliations
Review

Vitamin D and non-Hodgkin lymphoma risk in adults: a review

Jennifer L Kelly et al. Cancer Invest. 2009 Nov.

Abstract

Animal and human studies support a protective effect of vitamin D sufficiency related to malignancy by uncovering paracrine and autocrine effects of extra-renal 25-hydroxyvitamin D (25(OH)D) activation including regulation of cell cycle proliferation, apoptosis induction, and increased cell differentiation signaling. Recent epidemiologic studies demonstrate a reduction in non-Hodgkin lymphoma (NHL) risk with increased sunlight exposure. As sunlight is a major vitamin D source, it has been suggested that vitamin D status may mediate this observed association. This review provides a comprehensive discussion of the current epidemiologic evidence with regard to the investigation of an association between vitamin D status and NHL risk.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Proposed mechanism. It is hypothesized that extra-renal conversion of 25(OH)D to the active vitamin D metabolite (1,25(OH)2D) results in autocrine and paracrine signaling to control lymphocyte cell proliferation and decrease lymphoma risk.
See this image and copyright information in PMC

References

    1. Ries L, et al., editors. SEER Cancer Statistics Review, 1975–2004. National Cancer Institute; Bethesda, MD: 2005. http://seer.cancer.gov/csr/1973_2004/. Vol. based on November 2006 SEER data submission, posted to the SEER website, 2007.
    1. Fisher SG, Fisher RI. The epidemiology of non-Hodgkin's lymphoma. Oncogene. 2004;23(38):6524–34. - PubMed
    1. Grulich AE, Vajdic CM, Cozen W. Altered immunity as a risk factor for non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev. 2007;16(3):405–8. - PubMed
    1. Engels EA, Goedert JJ. Human immunodeficiency virus/acquired immunodeficiency syndrome and cancer: past, present, and future. J Natl Cancer Inst. 2005;97(6):407–9. - PubMed
    1. Baris D, Zahm SH. Epidemiology of lymphomas. Curr Opin Oncol. 2000;12(5):383–94. - PubMed

Publication types

MeSH terms