Comment
doi: 10.1016/j.immuni.2009.09.011.
A view to a kill: how ligand quality controls lethal hits
Affiliations
- PMID: 19833082
- DOI: 10.1016/j.immuni.2009.09.011
Item in Clipboard
Comment
A view to a kill: how ligand quality controls lethal hits
Immunity.
.
Free article
Abstract
In this issue of Immunity, Beal et al. (2009) and Jenkins et al. (2009) demonstrate that relatively weak stimuli support synapse formation and microtubule polarization, but fail to trigger efficient killing because of their inability to recruit lytic granules to the synaptic cleft.
Comment on
-
The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse.Immunity. 2009 Oct 16;31(4):621-31. doi: 10.1016/j.immuni.2009.08.024. Immunity. 2009. PMID: 19833087 Free PMC article.
-
Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain.Immunity. 2009 Oct 16;31(4):632-42. doi: 10.1016/j.immuni.2009.09.004. Immunity. 2009. PMID: 19833088 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
