Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Mar;37(3):493-502.
doi: 10.1016/j.nbd.2009.10.005. Epub 2009 Oct 13.

Inflammation in ALS and SMA: sorting out the good from the evil

Dimitra Papadimitriou  1 , Virginia Le Verche, Arnaud Jacquier, Burcin Ikiz, Serge Przedborski, Diane B Re
Affiliations
Review

Inflammation in ALS and SMA: sorting out the good from the evil

Dimitra Papadimitriou et al. Neurobiol Dis. 2010 Mar.

Abstract

Indices of neuroinflammation are found in a variety of diseases of the CNS including amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Over the years, neuroinflammation, in degenerative disorders of the CNS, has evolved from being regarded as an innocent bystander accomplishing its housekeeping function secondary to neurodegeneration to being considered as a bona fide contributor to the disease process and, in some situations, as a putative initiator of the disease. Herein, we will review neuroinflammation in both ALS and SMA not only from the angle of neuropathology but also from the angle of its potential role in the pathogenesis and treatment of these two dreadful paralytic disorders.

PubMed Disclaimer

References

    1. Almer G, Guégan C, Teismann P, Naini A, Rosoklija G, Hays AP, Chen C, Przedborski S. Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis. Ann Neurol. 2001;49:176–185. - PubMed
    1. Almer G, Vukosavic S, Romero N, Przedborski S. Inducible nitric oxide synthase upregulation in a transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem. 1999;72:2415–2425. - PubMed
    1. Apostolski S, Nikolic J, Bugarskiprokopljevic C, Miletic V, Pavlovic S, Filipovic S. Serum and Csf Immunological Findings in Als. Acta Neurol Scand. 1991;83:96–98. - PubMed
    1. Araki S, Hayashi M, Tamagawa K, Saito M, Kato S, Komori T, Sakakihara Y, Mizutani T, Oda A. Neuropathological analysis in spinal muscular atrophy type II. Acta Neuropathologica. 2003;106:441–448. - PubMed
    1. Banerjee R, Mosley RL, Reynolds AD, Dhar A, Jackson-Lewis V, Gordon PH, Przedborski S, Gendelman HE. Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice. PLoS ONE. 2008;3:e2740. - PMC - PubMed

Publication types

MeSH terms