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Review
. 1990 Jul;2(4):247-53.

The antigen processing pathway in B lymphocytes

C Watts  1 , P A Reid, M A West, H W Davidson
Affiliations
  • PMID: 1983338
Review

The antigen processing pathway in B lymphocytes

C Watts et al. Semin Immunol. 1990 Jul.

Abstract

Monovalent antigen bound to membrane immunoglobulin on human B lymphoblastoid cells is endocytosed through coated pits and passes sequentially from a site which actively recycles membrane to the cell surface and then to a proteolytically active processing site. A high affinity of immunoglobulin for antigen precludes antigen dissociation following endocytosis and results in the processing of an antigen/Ig complex yielding an epitope-specific pattern of processing. Processing of the immunoglobulin also occurs and is enhanced by occupancy with monovalent antigen.

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