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Comment
. 2009 Oct 15;23(20):2366-70.
doi: 10.1101/gad.1861709.

Developmental trajectories in early hematopoiesis

Cornelis Murre  1
Affiliations
Comment

Developmental trajectories in early hematopoiesis

Cornelis Murre. Genes Dev. .

Abstract

The paths that hematopoietic stem cells take to develop from multipotent, self-renewing cells into committed lymphocytes has been a topic of debate for some time. During early hematopoiesis, multiple branchpoints have been described in which progeny cells segregate into cell lineages with distinct developmental potentials. In this issue of Genes & Development, Inlay and colleagues (pp. 2376-2381) identify novel intermediate stages through which hematopoietic progenitor cells travel.

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Figures

Figure 1.
Figure 1.
Development of hematopoietic progenitors from the LT-HSC. The diagram shows the road map of early hematopoiesis. The revised map shows the newly defined and characterized ALP and BLP compartments. Transcription factors that act at distinct stages or transition during early hematopoiesis are indicated. (MkP) megakaryocytic progenitor; (CFU-E) colony-forming unit erythroid progenitor. Note that the CLP population is segregated into two distinct stages, named the ALP and the BLP compartments.
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