Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Nov;7(11):798-812.
doi: 10.1038/nrmicro2223.

Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs

Mayte Coiras  1 , María Rosa López-Huertas, Mayte Pérez-Olmeda, José Alcamí
Affiliations
Review

Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs

Mayte Coiras et al. Nat Rev Microbiol. 2009 Nov.

Abstract

HIV-1 can infect both activated and resting, non-dividing cells, following which the viral genome can be permanently integrated into a host cell chromosome. Latent HIV-1 reservoirs are established early during primary infection and constitute a major barrier to eradication, even in the presence of highly active antiretroviral therapy. This Review analyses the molecular mechanisms that are necessary for the establishment of HIV-1 latency and their relationships with different cellular and anatomical reservoirs, and discusses the current treatment strategies for targeting viral persistence in reservoirs, their main limitations and future perspectives.

PubMed Disclaimer

References

    1. Nat Med. 2006 Dec;12(12):1365-71 - PubMed
    1. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8869-73 - PubMed
    1. J Clin Immunol. 2001 May;21(3):218-26 - PubMed
    1. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4819-24 - PubMed
    1. J Biol Chem. 2004 Oct 29;279(44):46046-56 - PubMed

Publication types

Substances