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. 2009 Oct 16:9:77.
doi: 10.1186/1471-230X-9-77.

The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer

Xiaoxiang Guan  1 , Hui Zhao, Jiangong Niu, Dongfeng Tang, Jaffer A Ajani, Qingyi Wei
Affiliations

The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer

Xiaoxiang Guan et al. BMC Gastroenterol. .

Abstract

Background: Both TGF-beta1 and VEGF play a critic role in the multiple-step process of tumorgenesis of gastric cancer. Single nucleotide polymorphisms (SNPs) of the TGFB1 and VEGF genes have been associated with risk and progression of many cancers. In this study, we investigated the association between potentially functional SNPs of these two genes and risk of gastric cancer in a US population.

Methods: The risk associated with genotypes and haplotypes of four TGFB1 SNPs and four VEGF SNPs were determined by multivariate logistic regression analysis in 171 patients with gastric cancer and 353 cancer-free controls frequency-matched by age, sex and ethnicity.

Results: Compared with the VEGF-634GG genotype, the -634CG genotype and the combined -634CG+CC genotypes were associated with a significantly elevated risk of gastric cancer (adjusted OR = 1.88, 95% CI = 1.24-2.86 and adjusted OR = 1.56, 95% CI = 1.07-2.27, respectively). However, none of other TGFB1 and VEGF SNPs was associated with risk of gastric cancer.

Conclusion: Our data suggested that the VEGF-634G>C SNP may be a marker for susceptibility to gastric cancer, and this finding needs to be validated in larger studies.

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References

    1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74–108. doi: 10.3322/canjclin.55.2.74. - DOI - PubMed
    1. Jemal A, Siegel R, Ward E. et al.Cancer statistics, 2008. CA Cancer J Clin. 2008;58(2):71–96. doi: 10.3322/CA.2007.0010. - DOI - PubMed
    1. Peto J. Cancer epidemiology in the last century and the next decade. Nature. 2001;411(6835):390–395. doi: 10.1038/35077256. - DOI - PubMed
    1. Li T, Cao BW, Dai Y, Cui H, Yang HL, Xu CQ. Correlation of transforming growth factor beta-1 gene polymorphisms C-509T and T869C and the risk of gastric cancer in China. J Gastroenterol Hepatol. 2008;23(4):638–642. doi: 10.1111/j.1440-1746.2008.05324.x. - DOI - PubMed
    1. Liu DH, Zhang XY, Fan DM. et al.Expression of vascular endothelial growth factor and its role in oncogenesis of human gastric carcinoma. World J Gastroenterol. 2001;7(4):500–505. - PMC - PubMed

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