Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Feb;12(2):129-37.
doi: 10.1016/j.jfms.2009.08.006.

A dual-strain feline calicivirus vaccine stimulates broader cross-neutralization antibodies than a single-strain vaccine and lessens clinical signs in vaccinated cats when challenged with a homologous feline calicivirus strain associated with virulent systemic disease

Chengjin Huang  1 , Jennifer Hess, Michael Gill, David Hustead
Affiliations

A dual-strain feline calicivirus vaccine stimulates broader cross-neutralization antibodies than a single-strain vaccine and lessens clinical signs in vaccinated cats when challenged with a homologous feline calicivirus strain associated with virulent systemic disease

Chengjin Huang et al. J Feline Med Surg. 2010 Feb.

Abstract

Feline calicivirus (FCV) causes an array of clinical disease in cats. Traditionally this disease has been associated with respiratory disease, limping, or chronic stomatitis. Within the last 10 years, virulent systemic feline calicivirus (VS-FCV) has been recognized which causes additional clinical signs and has a higher fatality rate. A dual-strain FCV vaccine containing a strain of FCV associated with traditional respiratory disease and a VS-FCV strain stimulates serum cross-neutralization antibodies when tested against field strains from Europe and VS-FCV strains from USA. Following challenge with a homologous VS-FCV strain, vaccinated cats had significantly reduced clinical signs.

PubMed Disclaimer

References

    1. Radford A.D., Coyne K.P., Dawson S., Porter C.J., Gaskell R.M. Feline calicivirus, Vet Res 38, 2007, 319–335. - PubMed
    1. Pedersen N.C., Laliberte L., Ekman S. A transient febrile limping syndrome caused by two different strains of feline calicivirus, Feline Pract 13, 1983, 26–35.
    1. Pedersen N.C., Elliott J.B., Glasgow A., Poland A., Keel K. An isolated epizootic of hemorrhagic-like fever in cats caused by a novel and highly virulent strain of feline calicivirus, Vet Microbiol 73, 2000, 281–300. - PMC - PubMed
    1. Coyne K.P., Jones B.R., Kipar A., et al. Lethal outbreak of disease associated with feline calicivirus infection in cats, Vet Rec 158, 2006, 544–550. - PubMed
    1. Foley J., Hurley K., Pesavento P.A., Poland A., Pedersen N.C. Virulent systemic feline calicivirus infection: Local cytokine modulation and contribution of viral mutants, J Feline Med Surg 8, 2006, 55–61. - PMC - PubMed

Publication types

MeSH terms

LinkOut - more resources