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. 2010 Mar;209(1):271-7.
doi: 10.1016/j.atherosclerosis.2009.09.008. Epub 2009 Sep 12.

Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study

Edith Lubos  1 , Christoph R Sinning, Renate B Schnabel, Philipp S Wild, Tanja Zeller, Hans J Rupprecht, Christoph Bickel, Karl J Lackner, Dirk Peetz, Joseph Loscalzo, Thomas Münzel, Stefan Blankenberg
Affiliations

Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study

Edith Lubos et al. Atherosclerosis. 2010 Mar.

Abstract

Objective: Experimental data suggest a protective role of the essential trace element selenium against cardiovascular disease (CVD), whereas epidemiological data remains controversial. We aimed to investigate the impact of serum selenium concentration in patients presenting with stable angina pectoris (SAP) or acute coronary syndrome (ACS) on long term prognosis.

Methods: Baseline selenium concentration was measured in 1731 individuals (852 with SAP, and 879 with ACS). During a median follow-up of 6.1 years, 190 individuals died from cardiovascular causes.

Results: In those ACS patients who subsequently died of cardiac causes, selenium levels were lower compared to survivors (61.0microg/L versus 71.5microg/L; P<0.0001). In a fully adjusted model, patients in the highest tertile of selenium concentration had a hazard ratio of 0.38 (95% CI: 0.16-0.91; P=0.03) as compared with those in the lowest. No association between selenium levels and cardiovascular outcome was observed in SAP.

Conclusions: Low selenium concentration was associated with future cardiovascular death in patients with ACS.

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Figures

Fig. 1
Fig. 1
Kaplan–Meier curves for the proportional survival rate according to increasing tertiles of selenium concentrations for patients with stable angina pectoris (Panel A), acute coronary syndrome (Panel B) and cardiovascular mortality.
See this image and copyright information in PMC

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