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. 2009 Nov 15;17(22):7795-801.
doi: 10.1016/j.bmc.2009.09.028. Epub 2009 Sep 19.

Synthesis of bis-Schiff bases of isatins and their antiglycation activity

Khalid Mohammed Khan  1 , Momin Khan, Muhammad Ali, Muhammad Taha, Saima Rasheed, Shahnaz Perveen, M Iqbal Choudhary
Affiliations

Synthesis of bis-Schiff bases of isatins and their antiglycation activity

Khalid Mohammed Khan et al. Bioorg Med Chem. .

Abstract

Bis-Schiff bases 1-27 have been synthesized and their in vitro antiglycation potential has been evaluated. Compounds 21 (IC(50)=243.95+/-4.59microM), 20 (IC(50)=257.61+/-5.63microM), and 7 (IC(50)=291.14+/-2.53microM) showed an excellent antiglycation activity better than the standard (rutin, IC(50)=294.46+/-1.50microM). This study has identified a series of potential molecules as antiglycation agents. A structure-activity relationship has been studied, and all the compounds were characterized by spectroscopic techniques.

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