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. 2010 Jan;54(1):536-9.
doi: 10.1128/AAC.00714-09. Epub 2009 Oct 19.

In vitro activity of thimerosal against ocular pathogenic fungi

Yan Xu  1 , Guangren Pang, Dongqing Zhao, Chuanwen Gao, Lutan Zhou, Shengtao Sun, Bingliang Wang
Affiliations

In vitro activity of thimerosal against ocular pathogenic fungi

Yan Xu et al. Antimicrob Agents Chemother. 2010 Jan.

Abstract

The in vitro activity of thimerosal versus those of amphotericin B and natamycin was assessed against 244 ocular fungal isolates. The activity of thimerosal against Fusarium spp., Aspergillus spp., and Alternaria alternata was 256 times, 512 times, and 128 times, respectively, greater than that of natamycin and 64 times, 32 times, and 32 times, respectively, greater than that of amphotericin B. Thimerosal's antifungal activity was significantly superior to those of amphotericin B and natamycin against ocular pathogenic fungi in vitro.

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References

    1. Abrams, J. D., T. G. Davies, and M. Klein. 1965. Mercurial preservatives in eye-drops: observations on patients using miotics containing thimerosal. Br. J. Ophthalmol. 49:146-147. - PMC - PubMed
    1. Bhartiya, P., M. Daniell, M. Constantinou, F. M. Islam, and H. R. Taylor. 2007. Fungal keratitis in Melbourne. Clin. Exp. Ophthalmol. 35:124-130. - PubMed
    1. Chen, W. F., J. P. Wang, and G. B. Zhuang. 2000. Treating fungal keratitis with natamycin. Ophthalmol. CHN. 9:179-180.
    1. Chowdhary, A., and K. Singh. 2005. Spectrum of fungal keratitis in North India. Cornea 24:8-15. - PubMed
    1. Debbasch, C., F. O. Brignole, P. J. Pisella, and J. M. Warnet. 2001. Quaternary mmoniums and other preservatives' contribution in oxidative stress and apoptosis on Chang conjunctival cells. Investig. Ophthalmol. Vis. Sci. 42:642-652. - PubMed