The gut feeling of Treg cells: IL-10 is the silver lining during colitis
- PMID: 19841645
- DOI: 10.1038/ni1109-1141
The gut feeling of Treg cells: IL-10 is the silver lining during colitis
Abstract
Regulatory T cells that express the transcription factor Foxp3 are pivotal in suppressing autoimmune responses. A report in this issue describes a key role for interleukin 10 produced by lamina propria macrophages in maintaining Foxp3 expression during inflammatory responses in the intestine.
Comment on
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Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis.Nat Immunol. 2009 Nov;10(11):1178-84. doi: 10.1038/ni.1791. Epub 2009 Sep 27. Nat Immunol. 2009. PMID: 19783988 Free PMC article.
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