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. 2009 Sep 15;7(3):434-44.
doi: 10.3390/md7030435.

Two new jaspamide derivatives from the marine sponge Jaspis splendens

Sherif S Ebada  1 , Victor Wray, Nicole J de Voogd, Zhiwei Deng, Wenhan Lin, Peter Proksch
Affiliations

Two new jaspamide derivatives from the marine sponge Jaspis splendens

Sherif S Ebada et al. Mar Drugs. .

Abstract

Two new jaspamide derivatives 2 and 3, together with the parent compound jaspamide (1) have been isolated from the marine sponge Jaspis splendens collected in Kalimantan (Indonesia). The structures of the new compounds were unambiguously elucidated based on 1D and 2D NMR spectral data, mass spectrometry and comparison with jaspamide (1). The new derivatives inhibited the growth of mouse lymphoma (L5178Y) cell line in vitro with IC(50) values of <0.1 microg/mL.

Keywords: Jaspis splendens; cytotoxic activity; jaspamide Q and R; structure elucidation.

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Figures

Figure 1
Figure 1
New jaspamide derivatives 2 and 3, together with the parent jaspamide (1).
Figure 2
Figure 2
Key HMBC correlations of jaspamide Q (2).
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