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Randomized Controlled Trial
. 2010 Jan;30(1):11-6.
doi: 10.1038/jp.2009.170. Epub 2009 Oct 22.

Seven-month developmental outcomes of very low birth weight infants enrolled in a randomized controlled trial of delayed versus immediate cord clamping

J S Mercer  1 , B R Vohr, D A Erickson-Owens, J F Padbury, W Oh
Affiliations
Randomized Controlled Trial

Seven-month developmental outcomes of very low birth weight infants enrolled in a randomized controlled trial of delayed versus immediate cord clamping

J S Mercer et al. J Perinatol. 2010 Jan.

Abstract

Objective: The results from our previous trial revealed that infants with delayed cord clamping (DCC) had significantly lesser intraventricular hemorrhage (IVH) and late-onset sepsis (LOS) than infants with immediate cord clamping (ICC). A priori, we hypothesized that infants with DCC would have better motor function by 7 months corrected age.

Study design: Infants between 24 and 31 weeks were randomized to ICC or DCC and follow-up evaluation was completed at 7 months corrected age.

Result: We found no differences in the Bayley Scales of Infant Development (BSID) scores between the DCC and ICC groups. However, a regression model of effects of DCC on motor scores controlling for gestational age, IVH, bronchopulmonary dysplasia, sepsis and male gender suggested higher motor scores of male infants with DCC.

Conclusion: DCC at birth seems to be protective of very low birth weight male infants against motor disability at 7 months corrected age.

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Conflict of interest statement

Conflict of Interest

None of the authors have any conflict of interest to report.

Figures

Figure 1
Figure 1
Flow chart of children included in the Cord Clamping Study and 7 Month Follow-Up
Figure 2
Figure 2
Number of girls and boys in each PDI Score Range with delayed (D) or immediate (I) cord clamping at 7 Months corrected age. The difference between the boys with ICC and DCC is significant (p = 0.04). No difference was noted between the girls (p = 0.33).
See this image and copyright information in PMC

Comment in

References

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