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Review
. 2010 Apr;42(4):543-50.
doi: 10.1016/j.biocel.2009.10.011. Epub 2009 Oct 20.

The role of B cells in lupus pathogenesis

Emil Nashi  1 , YingHua Wang, Betty Diamond
Affiliations
Review

The role of B cells in lupus pathogenesis

Emil Nashi et al. Int J Biochem Cell Biol. 2010 Apr.

Abstract

Autoantibodies clearly contribute to tissue inflammation in systemic lupus erythematosus. In order to therapeutically target B cells making pathogenic autoantibodies, it is necessary to identify their phenotype. It is also important to understand the defects in B cell repertoire selection that permit pathogenic autoreactive B cells to enter the immunocompetent B cell repertoire. We present the data that both marginal zone and follicular B cells can produce pathogenic autoantibodies. Moreover, we discuss how B cell survival and maturation are regulated centrally prior to antigen activation and in the periphery after antigen activation to form the repertoire that generates the spectrum of circulating antibodies.

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