The IntAct molecular interaction database in 2010

Abstract

IntAct is an open-source, open data molecular interaction database and toolkit. Data is abstracted from the literature or from direct data depositions by expert curators following a deep annotation model providing a high level of detail. As of September 2009, IntAct contains over 200.000 curated binary interaction evidences. In response to the growing data volume and user requests, IntAct now provides a two-tiered view of the interaction data. The search interface allows the user to iteratively develop complex queries, exploiting the detailed annotation with hierarchical controlled vocabularies. Results are provided at any stage in a simplified, tabular view. Specialized views then allows 'zooming in' on the full annotation of interactions, interactors and their properties. IntAct source code and data are freely available at http://www.ebi.ac.uk/intact.

Figure 1.

The figure shows the interactions found after searching for Pubmed 16525503. Each row corresponds to one binary interaction with a list of evidences. Only the evidences matching the search criteria are shown in the results. In September 2009, 24 binary interaction evidences were found, 14 of which were originated from complexes and expanded using the Spoke model. Icons in the Name molecules fields show the type of molecule and the experimental and biological roles of the molecule in the context of the interaction. Links to Dasty2 and external resources such as UniProtKB or ChEBI are available too. Clicking on the magnifying glass icon in the first column or on the interaction accession number will direct the user to the details of that specific interaction evidence.

Figure 2.

The figure explains the ‘Find similar interactions’ matrix, which is accessible from the Details page.