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Review
. 2009 Nov;9(11):773-84.
doi: 10.1038/nrc2736.

Polycomb group proteins: navigators of lineage pathways led astray in cancer

Adrian P Bracken  1 , Kristian Helin
Affiliations
Review

Polycomb group proteins: navigators of lineage pathways led astray in cancer

Adrian P Bracken et al. Nat Rev Cancer. 2009 Nov.

Abstract

The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell fate decisions and how their deregulation potentially contributes to cancer. In this Review we discuss the emerging roles of long non-coding RNAs (ncRNAs) and a subset of transcription factors, which we call cell fate transcription factors, in the regulation of PcG association with target genes. We also speculate about how their deregulation contributes to tumorigenesis.

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