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. 2010 Mar 5;207(2):508-11.
doi: 10.1016/j.bbr.2009.10.020. Epub 2009 Oct 22.

Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

Panayotis K Thanos  1 , Rahila Habibi, Michael Michaelides, Ujval B Patel, Katherine Suchland, Brenda J Anderson, John K Robinson, Gene-Jack Wang, David K Grandy, Nora D Volkow
Affiliations

Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

Panayotis K Thanos et al. Behav Brain Res. .

Abstract

In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R(+/+)), both heterozygous (D4R(+/-)) and knockout (D4R(-/-)) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.

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Figures

Figure 1
Figure 1
Mean Lever Responses during Food and Cocaine Self-Administration
Figure 2
Figure 2
Mean Pellets and Infusions delivered during Food and Cocaine Self-Administration
See this image and copyright information in PMC

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