Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Nov 20;64(3):145-59.
doi: 10.1016/j.maturitas.2009.09.017. Epub 2009 Oct 23.

Longitudinal associations between depression and functioning in midlife women

Joyce T Bromberger  1 , T Lanza di Scalea
Affiliations
Review

Longitudinal associations between depression and functioning in midlife women

Joyce T Bromberger et al. Maturitas. .

Abstract

Associations between depression and impaired functioning are well known and have been documented in numerous clinical, primary care and epidemiological studies. Reviews of this research have focused on the elderly. Recent studies suggest that women become increasingly vulnerable during the menopausal transition to declines in physical and role function and increases in depressive symptoms. The purpose of the current research is to review the literature since 1966 for studies examining the association between depression and physical and psychosocial impairment in midlife women. We selected only longitudinal studies that had the potential to elucidate the nature of the complex relationship between depression and functioning. Results of the review indicate evidence for bi-directional associations between depression and functioning in middle-aged women. However, the studies are only broadly informative. Most adjusted for only a limited group of factors that could be associated with both depression and functioning. None of them directly examined potential moderators or mediators of the relationship between depression and impaired functioning.

PubMed Disclaimer

Figures

Figure n. 1
Figure n. 1
Sequential process of the articles selection
See this image and copyright information in PMC

References

    1. Coryell W, Scheftner W, Keller M, Endicott J, Maser J, Klerman GL. The enduring psychosocial consequences of mania and depression. Am J Psychiatry. 1993;150:720–7. - PubMed
    1. Wells KB, Stewart A, Hays R, Burnam MA, Rogers W, Daniels M, et al. The functioning and well-being of depressed patients. Results from the Medical Outcomes Study. JAMA. 1989 Aug;262:914–19. - PubMed
    1. Kessler RC, Zhao S, Blazer DG, Swartz M. Prevalence, correlates, and course of minor depression and major depression in the National Comorbidity Survey. J Affect Disord. 1997;45:19–30. - PubMed
    1. Kouzis AC, Eaton WW. Psychopathology and the development of disability. Soc Psychiatry Psychiatr Epidemiol. 1997;32:379–86. - PubMed
    1. Turner RJ, Beiser M. Major depression and depressive symptomatology among the physically disabled. Nervous & Disease. 1990 Jun;178(6):343–50. - PubMed

Publication types