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. 2010 Mar;117(1):13-20.
doi: 10.1016/j.schres.2009.09.030. Epub 2009 Oct 24.

Amplitude of low-frequency oscillations in schizophrenia: a resting state fMRI study

Matthew J Hoptman  1 , Xi-Nian Zuo, Pamela D Butler, Daniel C Javitt, Debra D'Angelo, Cristina J Mauro, Michael P Milham
Affiliations

Amplitude of low-frequency oscillations in schizophrenia: a resting state fMRI study

Matthew J Hoptman et al. Schizophr Res. 2010 Mar.

Abstract

Recently, a great deal of interest has arisen in resting state fMRI as a measure of tonic brain function in clinical populations. Most studies have focused on the examination of temporal correlation between resting state fMRI low-frequency oscillations (LFOs). Studies on the amplitudes of these low-frequency oscillations are rarely reported. Here, we used amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF; the relative amplitude that resides in the low frequencies) to examine the amplitude of LFO in schizophrenia. Twenty-six healthy controls and 29 patients with schizophrenia or schizoaffective disorder participated. Our findings show that patients showed reduced low-frequency amplitude in proportion to the total frequency band investigated (i.e., fALFF) in the lingual gyrus, left cuneus, left insula/superior temporal gyrus, and right caudate and increased fALFF in the medial prefrontal cortex and the right parahippocampal gyrus. ALFF was reduced in patients in the lingual gyrus, cuneus, and precuneus and increased in the left parahippocampal gyrus. These results suggest LFO abnormalities in schizophrenia. The implication of these abnormalities for schizophrenic symptomatology is further discussed.

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Figures

Fig. 1
Fig. 1
Group differences in ALFF (top) and fALFF (bottom), LH = left hemisphere, RH = right hemisphere, blue = higher in controls. Z value scale is to the right of each pair.
See this image and copyright information in PMC

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