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Review
. 2009 Dec 3;583(23):3758-63.
doi: 10.1016/j.febslet.2009.10.056. Epub 2009 Oct 23.

Mechanisms of COPI vesicle formation

Victor W Hsu  1 , Jia-Shu Yang
Affiliations
Review

Mechanisms of COPI vesicle formation

Victor W Hsu et al. FEBS Lett. .

Abstract

Coat Protein I (COPI) is one of the most intensely investigated coat complexes. Numerous studies have contributed to a general understanding of how coat proteins act to initiate intracellular vesicular transport. This review highlights key recent findings that have shaped our current understanding of how COPI vesicles are formed.

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Figures

Figure 1
Figure 1
Key components acting in COPI vesicle formation. For the initial step that involves the recruitment of key factors, GBF1 activates ARF1 and this process is likely to be facilitated by additional interactions with coatomer and cargo proteins. Subsequently, coatomer and ARFGAP1 act as coat components to drive both the early (budding) and late (fission) stage of vesicle formation. Their roles involve interaction with cargo proteins, which also achieves cargo sorting and thereby coupling vesicle formation with cargo sorting. For the fission stage, BARS in cooperation with PA are needed additionally. Not shown is the role of DAG, because its precise function in COPI vesicle formation remains to be resolved.
See this image and copyright information in PMC

References

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